As the 2025 MLB season progresses into Week 12, savvy fantasy baseball managers are on the lookout for potential waiver-wire pickups to bolster their teams. This week, several hitters are highlighted based on their low roster percentages across major platforms like ESPN and Yahoo.

Among the top recommendations is Ryan O'Hearn (BAL), who holds eligibility at both first base and the outfield and is especially valuable this week with only one left-handed pitcher facing him in a favorable schedule. Nathaniel Lowe (WSH) is also a noteworthy pickup, having shown consistent performance despite a lower roster rate. Meanwhile, Miguel Vargas (CHW) continues to perplex fantasy managers by remaining under the 50% threshold, despite his evident potential backed by impressive APR metrics.

For deeper leagues, consider Otto Lopez (MIA) and Thairo Estrada (COL), both having favorable matchups that could yield substantial points. Lopez has been showing signs of form with three consecutive top-100 finishes, while Estrada's return from injury has him primed for production. The landscape on the waiver wire is dynamic, with players like Eric Wagaman (MIA), proving to be solid options for those in need of versatile hitters.