Week 2 fantasy decisions center on high-profile wideouts and how injuries, matchups, and QB play shape ceilings. Pittman Jr. may see fewer targets against Denver’s Patrick Surtain II despite practicing; Waddle’s shoulder adds risk against New England if he suits up, while Jameson Williams could benefit from a softer Week 2 matchup with Chicago. Rome Odunze emerged as Caleb Williams’ favorite target early, Marvin Harrison Jr. faces Jaycee Horn’s shadow in a tough Week 2 tilt, and Olave, DeVonta Smith, Diggs, Zay Flowers, and Jeudy are all in the crosshairs of tough lineup calls. The Who Should I Start tool remains the quick path to a confidence-booster, letting you compare up to four players with format-aware projections and up-to-date news.

In short, Week 2 starts hinge on health plus matchup nuance: Lions WRs versus Detroit’s pass-friendly defense, Panthers’ cornerback matchups for Harrison Jr., and the ever-present WR1/WR2 balance in Philadelphia and Buffalo. The piece also highlights the tool’s improvements—tiles, bye-week awareness, and scoring-format options—so fantasy managers can build stronger, data-driven lineups in real time.

Zach Charbonnet’s Week 1 red-zone workload signals TD upside for Week 2, with him handling most goal-line chances even when Kenneth Walker III is involved. Rome Odunze emerged as Chicago’s top red-zone target, and Drake London flashed strong Week 1 usage for Atlanta, suggesting continued red-zone opportunities. The piece maps red-zone volume by team (Cardinals, Panthers, Falcons, Vikings, Bears, Browns, Ravens) and flags defenses that struggle there, plus matchup-driven upside for Week 2. Derrick Henry also showed TD potential beyond short-yardage in Week 1.

Caleb Williams faces Detroit after a Week 1 stumble, posting 210 yards and a modest 6.0 YPA as he struggles to connect downfield. His rushing ability keeps him in fantasy rosters, but Chicago’s passing window must tighten for upside. Detroit counters with Jared Goff, a productive floor, and Jahmyr Gibbs as a dynamic playmaker who chipped in with multiple receptions in the opener. Rome Odunze supplied a red-zone-ready weaponry moment for the Lions, signaling high-income upside if the offense remains efficient in the red area. Odds tilt toward Detroit at home, but Williams’ rushing threat keeps this NFC North clash intriguing for DFS and prop bettors.

The Bears must protect Williams and unlock play-making, while the Lions look to sustain a methodical, efficient attack. In-season fantasy bets should weigh Gibbs’ multi-purpose usage and Goff’s favorable venue advantage, against Williams’ upside in a high-leverage divisional matchup. Expect a close battle with strategic opportunities for upside plays in the passing game and timely rushing attempts.

Ford Field will roar for Detroit's 2025 home opener against Chicago, as Ben Johnson returns to the building he left for a division rival. Amon-Ra St. Brown promises boos on his podcast; Rome Odunze says Johnson is braced for a passionate crowd.

Johnson expects a playoff-like vibe and may rely on silent counts, while Dan Campbell stresses fundamentals after a Packers game misstep. The two coaches remain friends as they prepare to face Chicago.