Week 1 injury designations shape depth charts for Lions and Packers heading to Lambeau. Detroit has three players ruled out and seven on the questionable list, with Jamarco Jones, Trevor Nowaske and Sione Vaki officially out and Jones moving to IR. Giovanni Manu is one injury away from possible offensive action, and Detroit added Jacob Saylors to the active roster with Anthony Pittman elevated. Green Bay carries seven questionable names, including Micah Parsons, Zayne Anderson, Nate Hobbs, Jayden Reed, Dontayvion Wicks, Savion Williams and Barryn Sorrell, with Reed managing a Jones fracture and Parsons’ snap count expected to be limited.

Fantasy angles tilt toward Parsons’ limited workload and Reed’s status, while Manu could see a small Week 1 chance if Jones remains out. The Lions’ special teams take a hit with Nowaske and Vaki out, and Detroit will lean on the depth pieces stepping in for Week 1. Stay plugged into late-week updates for any shifts in designation that could unlock or cap fantasy upside.

Love's left-thumb recovery could limit Week 1 operation for the Packers, with LaFleur noting handoffs with the off hand have not occurred in practice and could alter the game plan against Detroit. Eight Packers were limited on Thursday, headlined by Reed, Wicks, Jenkins, and Anderson, while Reed and Hobbs returned to practice. Parson's status for Week 1 remains a question, and the ball-security emphasis suggests Green Bay may lean toward a safer, quicker-pass approach if Love can't grip the ball well. The clip of off-hand handoffs hints at a cautious offense with reduced play-action efficiency in a Week 1 environment where every possession matters for fantasy lineups.

Beyond the thumb issue, Reed, Wicks, and Williams loom as potential Week 1 targets, with Jenkins anchoring the line and Anderson providing defensive depth if cleared. Parson's uncertain Week 1 involvement adds a layer of risk for the Packers' back-end and run design. Fantasy managers should watch practice reports closely, monitor Reed's health impact, and recalibrate expectations for the Packers' offense until Love demonstrates full grip and trust in the handoff and play-action timing.

MarShawn Lloyd’s hamstring setback could sideline him for the Packers’ opener and possibly longer, clouding Green Bay’s Week 1 plan. Lloyd, who had been expected to back up Josh Jacobs, exited a preseason game after a 33-yard catch, and Matt LaFleur indicated he will miss time. The injury plague for Lloyd echoes his injury-laden rookie year, adding to a string of health concerns for Green Bay’s backfield and even impacting Jordan Love’s hand rehab timeline as Love works back from thumb surgery. The team also could be without Barryn Sorrell (knee) and Omar Brown (lung injury), leaving Green Bay’s depth chart unsettled as the regular season approaches.

Love’s potential early-season absence from full practice could pressure the offense toward a heavier run game and shorter passes, while defensive and practice-time variables leave fantasy managers in a wait-and-see mode. With Lloyd out, expect the Packers to lean more on veteran backs and a mix of receivers as they rebuild timing with a reshuffled lineup. Owners should monitor practice reports and any roster moves in the coming days.