Miami’s defensive front, led by Zach Seiler and Jaelan Phillips with Bradley Chubb chasing pressure, faces a Colts O-line that features Tanor Bortolini and Matt Goncalves entering full-time duty inside. Movement on the back end and Weaver’s scheme complicate decisions for the Colts’ QB, making interior protection and run establishment critical as they navigate a learning curve for two first-time starters.

Two rookie anchors and a stifling edge duo could tilt the balance, pushing the Colts to rely on discipline up front and quick, decisive plays. The matchup hinges on whether Indianapolis can control the line of scrimmage and whether Miami’s interior push and edge pressure disrupts timing in the Colts’ somemissed opportunities, shaping early-season fantasy leverage on both sides.

Three game-defining clashes loom in Colts-Dolphins Week 1: Zach Sieler vs Indianapolis interior blockers, Jonathan Taylor powering the Colts on the ground, and De'Von Achane with Miami's speed backfield testing Indy’s run defense and opening big-play chances for Tyreek Hill and Jaylen Waddle. Success hinges on Colts’ interior protection and Taylor’s burst, while Miami’s run-driven approach can tilt the fantasy lens toward Achane and the Dolphins’ receivers.

Miami's 2025 captains are Tua Tagovailoa, Alec Ingold, Zach Sieler, Aaron Brewer, Jordyn Brooks, and Bradley Chubb. Tyreek Hill was not voted a captain for the first time since joining in 2022, amid past comments about wanting to play elsewhere. Hill has indicated he may not be a captain this year, but he’s rehabbing an oblique and is expected to be ready for the Colts game. De'Von Achane is also nearing a return after calf trouble, adding to a versatile offense and league-tested leadership structure.