Two Monday night NFL games headline the slate: Houston at Tampa Bay to start the doubleheader, then Las Vegas at Los Angeles in a pivotal AFC West showdown. Houston looks to rebound after a low-scoring Week 1, while Tampa Bay aims to stay undefeated behind Mayfield’s late connection to Emeka Egbuka. In the nightcap, the Raiders, fresh from a win over New England, host the Chargers as KC stumbles to an 0-2 start, setting an early-season clash that could shape the division.

J.J. McCarthy’s high-ankle sprain sidelines Minnesota’s rookie QB for 2-4 weeks, elevating Carson Wentz to the starting role as Minnesota drops to 1-1 after a 22-6 SNF loss to Atlanta. The Vikings’ next test comes against Cincinnati, a team juggling its own QB situation. Fantasy managers should reassess Vikings pass-game expectations with Wentz under center and gauge how the Bengals’ QB instability might shape this Week 3-4 slate.

Week 2 injuries create a shifting fantasy landscape. Burrow’s turf-toe surgery sinks Cincinnati’s ceiling and thrusts Browning into a tough starter role. Fields’ concussion protocol and Daniels’ knee sprain keep multiple offenses in flux, while Ekeler’s season-ending Achilles reshapes Washington’s backfield. IRs for Hunt and Corbett and Beebe’s high-ankle out the Cowboys’ center and Panthers’ line, respectively, heighten concerns. Several top corners (Surtain II, Terrell, Johnson) carry medium to high risk, influencing matchup decisions across the league.

McCarthy's ankle sprain could sideline him 2-4 weeks, forcing Minnesota into a Week 3 QB shuffle with Carson Wentz starting and Jake Browning awaiting for Cincinnati if Burrow remains out. McCarthy flashed upside in Week 1 with two passing TDs and a rushing score, but Week 2 against Atlanta exposed the rookie's turnover risk. The injury timeline adds fantasy volatility to Vikings receivers and Bengals playmakers, while Wentz's veteran presence offers floor for Minnesota and Browning must prove he can manage the Bengals efficiently until Burrow returns.