Kalif Raymond exited with a neck injury after a collision with Samaje Perine, but the Lions expect the issue to be not serious even as his Week 6 availability remains in doubt against Kansas City. Terrion Arnold also left with a shoulder problem, further thinning Detroit’s secondary. Isaac TeSlaa stepped in at No. 3 receiver and snagged his second TD, while Dominic Lovett handled punt returns.

With D.J. Reed on injured reserve and Khalil Dorsey sidelined, the Lions must lean on a reshaped defensive backfield as Rock Ya-Sin and Amik Robertson pick up extra duties. The injury situation will heavily influence fantasy lineups and Detroit’s target distribution heading into the Chiefs matchup.

Season metrics are stabilizing as we near the quarter mark, with offensive pace, pass-rate over expectation, and per-position defense data guiding Week 5 bets. Key targets and tailbacks across high-volume offenses are spotlighted, with clear highs and deliberate fades based on matchup and workload.

Top-WR plays lean on expected volume: Jeudy in Cleveland should see a hefty target share against Minnesota, Wilson stays locked in for massive target volume against Dallas, and Diggs brings a strong floor with a narrative edge as he faces his old team. Tight ends and running backs get upside pushes from favorable scripts and lingering injury/role shifts, while several backs face tougher boxes and reduced workloads that temper their upside.

Use this framework to build lineups and props: lean into volume and pace metrics, factor in opponent pass/funnel tendencies, and watch early in-game targets to adjust on the fly as roles crystallize across the league.

Denver hosts Cincinnati in Week 4’s MNF, with Browning’s two 2025 appearances underscoring a fragile QB plan for Cincinnati. A rough Week 3 exposed riskier, off-script plays that backfired, pressing the Bengals to lean on safer looks and their patchwork line. Cincinnati’s upgrades—Fant’s hybrid TE role and Risner’s adaptation—give them sporadic pop, while Stewart and Battle offer defensive upside. Denver’s matchup leans on containment of Browning and exploiting Cincinnati’s o-line, leading to a Broncos edge around 24-14.

The Bengals’ recent roster moves loom large: Fant’s versatility could stress Denver’s coverage, Battle keeps climbing as a playmaker, and Hendrickson must deliver a disruptive shift to turn the tide. Fantasy managers should watch Bet on the Bengals’ players who can capitalize when Browning minimizes mistakes, but Denver’s home-field advantage and improved run defense remain pivotal in this MNF clash.

Cincinnati travels to Denver for a high stakes Monday night clash, navigating a string of injuries that strain their offense. Joe Burrow deals with a toe issue while tight end Noah Fant and rookie edge Shemar Stewart are ruled out, concussion protocol sidelines Fant. Cam Taylor-Britt returns to the secondary, and Risner and Perine are cleared after last week, though the right guard spot may see rookie Jalen Rivers. Kickoff is 8:15 p.m. ET on ESPN/ABC.

The offensive line has been a recurring concern, and Fant and Stewart absence could shift targets and rushing dynamics. Monitor Risner status and Rivers’ snaps as Cincinnati leans on the run game and a possibly limited Burrow, with Denver's pass rush lurking in Mile High.