The 2025 NFL preseason kicks off with a multi-game DFS slate featuring the Colts vs Ravens, Bengals vs Eagles, and Raiders vs Seahawks. DraftKings and FanDuel offer lucrative contests such as the $150k Preseason Special and $25k Preseason Rush.

Strategic lineup construction is key, with fewer established starters likely to play, making it essential to target younger talent and those on the roster bubble. For quarterbacks, Anthony Richardson is one to watch as he battles for the starting job with Daniel Jones, showcasing his dual-threat capabilities. In the backfield, rookies like Tahj Brooks are expected to see significant carry opportunities, while wide receivers like Tory Horton are setting themselves apart in training camp.