Guillotine Leagues demand ruthless planning: master the scoring system to price positions, draft with a now-forward mindset, and secure a rock-solid waiver plan before the draft. Embrace cynicism, cut risk early, and exploit weekly talent infusions from waivers as eliminations roll in. Target top-10 players at key spots, avoid long-term rookies, and balance proven producers with a few calculated bets. This guide uses real-life examples to show how the right cuts and claims can tilt a season.