Week 2 features a slate-shaping set of one-on-one battles that fantasy managers should circle. A.J. Brown takes on Trent McDuffie in a high-stakes rematch, while Chris Jones faces Landon Dickerson inside the trenches. D.K. Metcalf meets Tariq Woolen, and Tyreek Hill battles Carlton Davis in a divisional spotlight. The piece prioritizes rhythm, route running, and line play as key differentiators for weekly production and DFS leverage.

Beyond the headline duels, Nabers vs Diggs and London vs Murphy Jr. add subtle but meaningful fantasy threads, with Garrett vs Stanley and Highsmith vs Cross offering high-floor, high-ceiling angles on both sides of the ball. The analysis emphasizes how these micro-matchups can tilt game flow and fantasy outcomes, guiding start/sit decisions and streaming options for Week 2.