The Detroit Lions faced a tumultuous 2023 season marked by several key injuries that disrupted player performance and team dynamics. James Houston's promising rookie year was halted by a severe right ankle injury, leading to his release midway through the following season. Meanwhile, Sam LaPorta's knee scare turned into a success story, as he bounced back to play all but one game in 2024. The Lions enjoyed overall good health, with only a few long-term injuries affecting their championship run.

Emmanuel Moseley, after suffering an ACL tear in his second game, struggled to regain his form and ended up unsigned as a free agent. Alim McNeill's toughness was evident through his MCL sprain, leading to a contract extension, while CJ Gardner-Johnson's absence created opportunities for younger players. Jonah Jackson's injury woes hindered his performance, leading to a move to the Rams. Despite a season without concussions, the Lions faced challenges that would affect their playoff aspirations.