Week 2 fantasy QB rankings for 2025 spotlight the same mix of elite ceiling and plus-matchup upside that fantasy managers crave. Justin Fields’ rushing floor keeps him in QB1 territory, while Caleb Williams anchors a high-upside Bears offense as a top weekly option in Superflex. Mac Jones enters with a favorable Saints test, and Patrick Mahomes faces a stiff challenge in a rematch against Philadelphia. J.J. McCarthy and Michael Penix Jr. sit as strong Superflex plays, with several veterans and youngsters rounding out the top tiers.

The Week 2 outlook emphasizes risk-reward: injuries and known blockers shift the value of several signal-callers, from Purdy’s out to Mahomes’ matchup dynamics, shaping lineup decisions for fantasy managers who need big weeks from their QBs to carry squads into the weekend.