The Detroit Lions have aspirations of a prime-time match-up to open the 2025 NFL season, particularly against the Philadelphia Eagles. However, they will not feature in the international games and have missed out on the coveted opening matchup, which has been awarded to the Dallas Cowboys. Amon-Ra St. Brown previously expressed eagerness for this matchup following the Eagles' Super Bowl victory, reflecting a strong belief in the Lions' competitive standing.

Cornerback Terrion Arnold also voiced his disappointment over not being selected for this prestigious early game. The Lions, looking to capitalize on their momentum, are keen to enhance their national profile and demonstrate their growth in the league. With a strong roster and increasing expectations, the team's aspirations for a marquee season opener highlight their ambitions as they aim to establish themselves as playoff contenders.