Five wide receivers stand out as potential league-winning picks in the middle rounds of 2025 drafts. The shift toward two-running-back early starts has inflated value at wideout in most rounds, making mid-round targets crucial for cap and volume. DeVonta Smith, Jaylen Waddle, Stefon Diggs, Josh Downs, and Ricky Pearsall are highlighted as undervalued by ADP and ready to deliver big weeks when deployed in the right matchups. The piece emphasizes that genuine WR upside exists across most rounds, especially for players attached to high-octane offenses or those stepping into clearer target roles due to roster changes.

DeVonta Smith anchors the Eagles’ aerial attack, with high floor and ceiling if A.J. Brown is limited. Waddle presents bounce-back upside after a down year, provided Miami’s health and QB stability align. Diggs, entering a later-career phase, could be a steal if Drake Maye’s offense clicks and Diggs becomes Maye’s trusted top target. Downs and Pearsall are slot-and-depth targets with significant upside if Colts and 49ers offenses keep throwing and injury luck tilts in their favor. The narrative ties these five to a broader strategy: nail your mid-round WRs to complement early RBs and any splashy QB choices.