Philadelphia's Week 6 prep ahead of Thursday's clash with the New York Giants centers on a thin injury sheet. Landon Dickerson (ankle) and Grant Calcaterra (oblique) are listed as non-participants, while Saquon Barkley (knee) is also DNP. The situation could pressure the Eagles' interior blocking and shape Giants' backfield usage in a short week.

Nakobe Dean is a full participant, with Jihaad Campbell (biceps) and Byron Young (triceps) limited as Philadelphia conducts a walk-through on Tuesday. Depth questions and week-long game-planning will drive projections for fantasy managers heading into Week 6.

Denver heads to Philadelphia in Week 5 with a sharpened run game thanks to Nate Adkins’ return and Quinn Meinerz back at guard, while Lucas Krull is out. Engram and Trautman provide reliable TE targets, and Adkins’ clearance keeps the offense balanced as Marvin Mims Jr. and Alex Singleton contribute in the receiving and tackling roles. The Eagles counter with Nakobe Dean OUT and Jihaad Campbell back, but questions linger around Dallas Goedert, Jalen Carter, and Lane Johnson. The clash could hinge on Denver’s ground attack volume and Philadelphia’s midseason adjustments.

The first-quarter PFF snapshot shows Philadelphia’s offense mixing solid line play with uneven pass-game usage. Landon Dickerson, Tyler Steen and Cam Jurgens pace the run-blocking grades, while Grant Calcaterra’s 34.02 stands out as a clear low. Kylen Granson and Darius Cooper post mid-range numbers with modest snap counts, and the receiving group isn’t pulling away despite multiple targets. Saquon Barkley remains the clearest fantasy standout outside Philly, with three rushing TDs in four games as the Giants lean on his production. Jahan Dotson also posts a usable mid-grade while the Eagles’ receivers chip in at various levels. Buffalo stays undefeated and Denver looms, creating a tense divisional stretch for Philadelphia.