Dominating a fantasy football draft can be achieved through the 'Hero RB' strategy, which emphasizes selecting one elite running back while postponing further running back acquisitions. This approach allows managers to capitalize on the best players available while maintaining flexibility during the draft. The importance of adapting to the draft flow is highlighted, suggesting that the best player available should guide selections rather than sticking rigidly to pre-defined strategies.

In the podcast, various drafting strategies are put forth, including mixing in rookie running backs and leveraging depth at wide receiver. The discussion emphasizes the potential of drafting players like Bucky Irving and Jalen Hurts, showcasing the advantages of a well-balanced team structure that still adheres to the Hero RB philosophy.