Week 2 features a marquee rematch as the Kansas City Chiefs host the Philadelphia Eagles, a payoff rematch from Super Bowl LVIII. Philly opened 2025 with a 24-20 win over Dallas, while KC threads a rebound after a Sao Paulo setback to the Chargers. Arrowhead kicks at 4:25 p.m. ET. Eagles are 1.5-point favorites with an over/under of 47; Hurts is lined for 217.5 passing yards. The SportsLine model pegs Philly to cover roughly half the time as both teams push for momentum.

Philly travels to Kansas City for Week 2 in a high-stakes rematch, with the Eagles bringing a potent, multi-pronged attack and the Chiefs facing injury-adapted WR depth. Worthy’s shoulder and Rashee Rice’s suspension thin KC’s arsenal, nudging the spread toward Philadelphia and putting more pressure on Mahomes to improvise.

The Eagles’ front will test a banged-up KC offense, while Vic Fangio’s defense aims to keep the Chiefs in check. Fantasy angles lean heavy on Philadelphia receivers, with the team predicted to press early and often. Final score: Eagles 31, Chiefs 20; Best Bet: Eagles -1.5.

Watch for line movement and matchup-driven props, especially on Brown and DeVonta Smith, as Philly looks to exploit KC’s depth and keep the crowd momentum in their favor.

Marquise Brown remains in play for Week 2 despite an ankle issue, with KC signaling he’s practicing and ready to suit up against the Eagles. If Brown is limited or rotates out snaps, Kansas City’s target tree tightens around JuJu Smith-Schuster and Nikko Remigio, while Tyquan Thornton could enter the mix as a depth option. The Week 1 loss to the Chargers underscores the need for reliable secondary options behind Brown and Mahomes.

Brown’s availability will largely determine the Week 2 game plan. If he’s healthy and active, expect a balanced Kansas City attack with ample关注 for Brown; if not, Smith-Schuster and Remigio become the primary sources of volume, elevating their fantasy ceilings in a challenging matchup.