The 2025 NFL Kickoff features the defending champions, Philadelphia, hosting Dallas in a high-profile Week 1 showdown that could set fantasy trajectories for the season. Hurts offers dual-threat upside, Prescott returns for Dallas, and the narrative includes Barkley’s heavy workload, plus WR targets Pickens and Lamb stepping into prominent roles. Slay’s exit and the rookie corners for Philly add defensive-notes for lineup decisions. The model tilts toward an Over 46 with Philly favored by seven, underscoring a potential shootout feel.

The matchup’s history matters: Philly owned the 2024 meetings, Barkley’s volume looms large for ground games, and Lamb remains a target machine. Pickens adds splash potential as a vertical option, while Slay’s absence could open opportunities for Philly’s young corners. With Mukuba and Sydney Brown-in-waiting for Philly, Week 1 also offers early defensive blueprint signals for fantasy benches and streaming options.

Overall, expect a charged atmosphere, early-season adjustments, and plenty of fantasy angles—from Hurts’ rushing to Lamb and Pickens’ ceilings to the spread and total that encourage diversified rosters and bold bets.