As the 2025 NFL season approaches, the Arizona Cardinals are set to encounter a daunting challenge in the latter part of their schedule, facing four of the league's top 12 quarterbacks in five of their final six games. Notably, they will take on Joe Burrow of the Cincinnati Bengals, Matthew Stafford of the Los Angeles Rams, Baker Mayfield of the Tampa Bay Buccaneers, along with honorable mentions CJ Stroud and Jordan Love. While Kyler Murray, the Cardinals' own quarterback, garnered some top-10 votes, he was not included in the official rankings.

With the Cardinals facing such formidable opponents late in the season, questions arise about their ability to contend with elite quarterbacks. Key matchups include their games against Stafford, whom they play twice, and Burrow, who will be in the spotlight in Week 17. The team's performance in these high-stakes encounters could heavily influence their playoff aspirations.

Despite avoiding many of the top-tier quarterbacks early in the season, the late-game gauntlet could expose vulnerabilities in Arizona's defense, leading to critical impacts on their standings if they struggle to adapt. Fantasy players should monitor these matchups closely, particularly how the Cardinals' defense fares against elite quarterbacks, which could affect the fantasy value of their players.