Five NFL players currently on IR, PUP, or NFI headlines for Week 1 of 2025: Brandon Aiyuk, Joe Mixon, Christian Watson, Jalen Coker, and Jalen McMillan. Aiyuk and Watson are on PUP with ACL injuries, Mixon starts on NFI amid ankle concerns, Coker is on IR with a quad, and McMillan heads to IR after a neck injury. The piece offers timelines and stash guidance for fantasy managers, highlighting ramped returns and the safety of IR spots, plus how rosters should weigh rest-of-season upside versus early-season risk.

Expect limited immediate fantasy impact from Aiyuk and Watson as they ease back, with late-season upside if they return around the back-half of the year. Mixon remains a high-uncertainty hold with potential RB2 upside if he returns, while Coker and McMillan represent deeper stash options whose roles hinge on who returns for their teams and the evolving WR corps. The piece emphasizes IR stash strategy and keeping eyes on target volume shifts as schedules unfold.