Two division leaders collide in Tampa as the 4-1 San Francisco 49ers visit the 4-1 Tampa Bay Buccaneers in a clash shaped by injuries and playoff seeding. Purdy’s availability looms large for San Francisco while Tampa Bay navigates battered receivers and an unsettled line. Emeka Egbuka shines as a breakout talent for the Buccaneers, and Baker Mayfield aims to sustain high-volume production against a thinner Bucs defense. Depth, coaching, and game plan will decide the fantasy upside in this high-stakes showdown.