Fred Warner’s season-ending ankle injury compounds a 49ers defense already ravaged by Nick Bosa’s torn ACL, with Purdy, Kittle and Aiyuk also dinged. Ji’Ayir Brown is thrust into bigger duties as the defense retools, while Tampa Bay’s Rachaad White keeps the Buccaneers’ ground game rolling. Jauan Jennings battled through five broken ribs and ankle sprains in Week 6. The ripple effects hit fantasy lineups and defensive metrics, reshaping upcoming matchups for SF and TB.

Expect the 49ers to lean on younger linebackers and scheming to mitigate the loss, while Brown and others in the depth chart get increased exposure in IDP formats. Bosa’s absence compounds the pass rush and run defense strain, making matchup-specific projections more volatile for the SF defense and elevating the value of opposing offenses against them.