Week 2 of the 2025 NFL preseason pits the Pittsburgh Steelers hosting the Tampa Bay Buccaneers at Acrisure Stadium. In Week 1, Pittsburgh topped Jacksonville 31-25 as Skylar Thompson piled up 233 yards and three touchdowns, while Mason Rudolph went 9-for-10 for 84 yards and a score. Tampa Bay opened with a 29-7 win behind Owen Wright and Sean Tucker on the ground and a defense that forced three interceptions. This game will spotlight backups and depth chart contests as teams tune for the regular season, with local TV in Pittsburgh (CBS 2) and Tampa (NBC 8) and NFL+ streaming out-of-market games. TB is favored by 3 with an over/under of 38.5 per BetMGM. The rest of Week 2 features Browns-Eagles, Patriots-Vikings, and more, giving fantasy players a read on early-season depth roles and potential late-round DFS values.