Warner's season-ending injury shakes the 49ers, amplifying a pattern of key losses and forcing a rapid retooling of defense and depth. San Francisco must lean on untested linebackers and Nick Martin while the offense struggles to sustain a ground game behind a leaky interior line. Brock Purdy faces more pressure, McCaffrey’s burst looks muted, and the defense must adapt without Bosa and Warner. The result is a reality check on 2025 plans and a push to find immediate answers on roster and scheme.