Chicago opens 2026 at home vs Nationals, then hosts Angels before a road trip to Cleveland. The balanced MLB schedule guarantees Chicago faces 29 teams in a series across 162 games, with interleague dates at Wrigley against Astros, Athletics, Blue Jays, Twins, Tigers, and Yankees. Crosstown six-game slate vs White Sox (May at Rate Field, Aug at Wrigley) stands out. May meetings with Reds and Brewers punctuate the NL Central focus; late-season trips include Rays, Rangers, Orioles, Royals, Mariners and Red Sox.