The Boston Red Sox face the Cleveland Guardians for the second game of their doubleheader, with Cleveland having narrowly edged out a win in the first game, 5-4. Manager Alex Cora has made strategic adjustments to the lineup, favoring right-handed hitters like Rob Refsnyder and Romy Gonzalez against the left-handed Doug Nikhazy, who is debuting in the majors. Refsnyder will occupy right field while Abreu sits, following a standout performance where he hit a three-run homer in the first match. Meanwhile, Walker Buehler is set to start for Boston after a solid season, positioned to contend against a fresh rookie in Nikhazy.