Jose Altuve exited the game in the third inning against the Cincinnati Reds due to tightness in his right hamstring. This occurred while the Astros were trailing significantly, 12-1. Altuve, who has been primarily playing in left field this season, recorded a walk and scored in the first inning before being substituted by Brendan Rodgers.

At 35, Altuve is currently batting .259 with four home runs and 14 RBIs. The team's struggles are compounded by his potential absence, making his health a key concern for Houston as they seek to improve their performance this season.