On July 22, 2025, MLB player prop bets highlight several hitters poised for home runs. Kyle Manzardo from the Cleveland Guardians is showcasing excellent form, recently hitting a homer and facing a susceptible righty, Brandon Young. Addison Barger of the Toronto Blue Jays is also a hot pick, coming off a recent home run and facing another rookie, Cam Schlittler, who struggled in his debut. Alec Burleson is noted for his strong performance against right-handed pitchers, especially in Coors Field, making him a potential candidate to hit one out.

Other notable mentions include Nick Castellanos, who thrives against pitchers with high HR/9 statistics, and Cam Smith of the Houston Astros, who has demonstrated significant power against left-handers. With appealing odds for these players, fantasy sports enthusiasts and bettors may find strategic opportunities to capitalize on their current trends and matchups.