Friday's MLB DFS slate presents a captivating lineup of players to target across DraftKings and FanDuel. With 12 games on the main slate, the strategy centers on key pitching matchups and explosive hitting potential. Hunter Brown of Houston stands out as a top pitcher, boasting a stellar 1.67 ERA, while Max Meyer is poised for a rebound against the struggling Chicago White Sox. For hitters, premium options like Adley Rutschman and Fernando Tatis Jr. are ready to shine in favorable matchups, making them essential components of a winning lineup.

Stacks to consider include the San Diego Padres, who face off against Antonio Senzatela of Colorado, and a game stack featuring the New York Yankees and Oakland Athletics. Each presents unique opportunities for point accumulation given their striking matchups. Overall, staying updated on injury news and lineup changes will be crucial as the slate progresses.