Expert NRFI betting predictions are back strong for MLB's July 21, 2025 slate. After a perfect 4-0 on the last round, the focus is on four matchups where pitching dominance meets struggling offenses. Key highlights include the Detroit Tigers against the Pittsburgh Pirates, where Paul Skenes, boasting a 20-0 NRFI record, faces a faltering Tigers lineup. Similarly, the Kansas City Royals take on the Chicago Cubs, where the wind at Wrigley favors pitchers, enhancing Noah Cameron's 10-2 NRFI record. Brandon Woodruff's return from injury also positions the Brewers against the Mariners, riding a ten-game NRFI streak. Lastly, the game featuring the Twins and Dodgers promises excitement with Shohei Ohtani and David Festa on the mound. Each matchup is vital for those betting on NRFI trends.