Pittsburgh heads to Fenway Park for a three-game set with Boston, highlighting Paul Skenes as the core fantasy focal point. Skenes carries NL Cy Young chatter and massive strikeout upside on the road, even in a hitter-friendly park. Boston’s depth and Fenway quirks add risk, but the upside remains strong for DFS lineups that chase Ks and a strong win chance if Pitt backs him.

The series also features roster shake-ups, notably Andrew Heaney being DFA’d, which tightens Pirates bullpen leverage and could tilt late-inning outcomes. Fantasy managers will watch how this affects bullpen usage and whether Sox batters can capitalize on any relief-carryover in games ahead.

Overall, this clash blends high-ceiling pitching with park and bullpen variables that can swing daily fantasy value. Skenes’ upside remains the marquee draw, while the bullpen shifts and Sox offense opportunities offer meaningful, contingent upside for the weekend slate.