On May 21, the Cincinnati Reds (25-25) faced off against the Pittsburgh Pirates (16-33) in a matchup featuring pitchers Brady Singer and Andrew Heaney. The Pirates held the Reds to just five hits, culminating in a five-hit shutout victory, which broke a four-game losing streak for Pittsburgh while snapping Cincinnati's five-game winning streak. This match showcased the Pirates' resilience as they fought through a challenging season. The Reds, struggling with an offense that has been shut out eight times this season, faced a tough task against the Pirates' pitching.

The betting landscape for this game favored the Reds at -127, with a spread of -1.5, while total runs were set at 8.0. Despite the odds, the Reds have found it hard to maintain momentum on the road, with the Under hitting in 31 of their last 50 away games. Fans and bettors alike seek insights on player performances and trends as they head into this game, looking for valuable betting opportunities based on recent form.