Houston Texans running back Joe Mixon remains in question for 2025, landing on the PUP list with a lingering foot/ankle issue. The offseason reality: health can stall, surgery isn’t ruled out, and Week 1 seems unlikely. Fantasy managers should brace for early-season absence and plan contingency RBs. The backdrop includes a run‑heavy Houston scheme and turnover at the coordinator spot, which could influence how big a role the starter gets when active.

Texans rook Woody Marks could absorb extra workload if Mixon is slow to return, while MarShawn Lloyd’s ankle history (with Green Bay) underscores the risk for Mixon’s timetable. As chatter swirls, draft plans should factor a cautious timeline, possible split work, and a strong fallback in Week 1 projections as the season unfolds.

Week 2 of the NFL preseason delivered a clear signal: Jaxson Dart is emerging as the league’s standout rookie quarterback through two exhibitions, completing 26 of 35 passes for 291 yards with two touchdowns across Giants performances. His poise, accuracy on middle throws, and a slick fake that freed Greg Dulcich for a score hint at a real developmental arc in New York’s QB competition. TreVeyon Henderson flashed burst and patience, hinting at a meaningful early role for New England, while Teddy Bridgewater delivered a couple of red-zone darts that underscored his value as a trusted veteran in Tampa Bay. Philadelphia rookie Andrew Mukuba showed a nose for the football with a pick-six and a fumble recovery, offering a potential secondary option for a rebuilding secondary. On the downside, MarShawn Lloyd’s lingering injury woes and the Cowboys’ backup shakeups stalled fantasy optimism, Joe Milton III struggled for Dallas, Van Jefferson combined a clean route with a missed catch, and Stafford’s unclear return schedule cast a cloud over the Rams’ offensive window. Week 2 left managers with a mix of fresh optimism and cautious notes as rosters thin and roles sharpen.

MarShawn Lloyd’s hamstring setback could sideline him for the Packers’ opener and possibly longer, clouding Green Bay’s Week 1 plan. Lloyd, who had been expected to back up Josh Jacobs, exited a preseason game after a 33-yard catch, and Matt LaFleur indicated he will miss time. The injury plague for Lloyd echoes his injury-laden rookie year, adding to a string of health concerns for Green Bay’s backfield and even impacting Jordan Love’s hand rehab timeline as Love works back from thumb surgery. The team also could be without Barryn Sorrell (knee) and Omar Brown (lung injury), leaving Green Bay’s depth chart unsettled as the regular season approaches.

Love’s potential early-season absence from full practice could pressure the offense toward a heavier run game and shorter passes, while defensive and practice-time variables leave fantasy managers in a wait-and-see mode. With Lloyd out, expect the Packers to lean more on veteran backs and a mix of receivers as they rebuild timing with a reshuffled lineup. Owners should monitor practice reports and any roster moves in the coming days.

Green Bay’s postgame update flags three fresh injuries from the Colts game: safety Omar Brown dealing with a chest contusion and staying overnight in Indianapolis for evaluation, rookie Barryn Sorrell nursing a knee injury, and running back MarShawn Lloyd whose status is listed as unknown after a hard take-down late in the first half. Brown’s chest issue required cart/oxygen support during Family Night visuals, underscoring how precautionary measures are shaping the Packers’ depth right now.

Sorrell, Green Bay’s fourth-round pick, left the field with knee concern after a punt play and did not return, leaving a potential edge depth question for the defense. Lloyd, who had just returned from a groin issue in padded practice, exited after a 33-yard grab and a shoulder hit, with coach Matt LaFleur hedging on his timetable.

Fantasy managers should watch how Green Bay assigns roles behind the top backs and safeties in the coming days. Brown’s chest contusion could push the safety rotation toward veterans or third-string help, Sorrell’s knee adds to the comings-and-goings in the pass rush rotation, and Lloyd’s prognosis could shift early-down back decisions and goal-line touches if he misses time.

Josh Jacobs returns to fantasy prominence in 2025 with Green Bay as his home base, a run-first scheme that should keep his TD opportunities plentiful and solid volume intact after a strong 2024 season. Jacobs posted 1,329 rushing yards, 16 total TDs, and 36 receptions in a year when he outperformed expectations in a crowded backfield. The Packers’ depth backs, MarShawn Lloyd and Emanuel Wilson, bring potential change-of-pace contributions, but Jacobs remains the clear lead option. The 2025 projection backs this up: 263 carries for 1,263 yards (4.8 APY) and 10 rushing TDs, plus 38 receptions for 294 yards and 2 receiving TDs, totaling roughly 13 TDs and around 270 fantasy points in standard formats. In a run-heavy system, he’s a stable RB1, though handcuffs Lloyd and Wilson could push upside when goal-line touches are scarce. The fantasy takeaway is trust Jacobs as the centerpiece while monitoring the backfield for late-round depth those players could carve out in the GB attack.

Behind the numbers, the outlook signals Jacobs’ role is secure, not merely a product of one season in a favorable setup. The year-by-year arc suggests Jacobs can sustain big-volume output if he stays healthy and cobbles together efficient drives. With Lloyd healthy and Wilson in the mix, the GB backfield offers a glimmer of instability in the later rounds, but Jacobs’ path to top-tier fantasy production remains clear. Fantasy managers should target him as an anchor RB1, with Lloyd and Wilson serving as intriguing late-round fliers or insurance handcuffs who could shift value if the Packers expand their usage early in the year.