Houston Texans running back Joe Mixon remains in question for 2025, landing on the PUP list with a lingering foot/ankle issue. The offseason reality: health can stall, surgery isn’t ruled out, and Week 1 seems unlikely. Fantasy managers should brace for early-season absence and plan contingency RBs. The backdrop includes a run‑heavy Houston scheme and turnover at the coordinator spot, which could influence how big a role the starter gets when active.

Texans rook Woody Marks could absorb extra workload if Mixon is slow to return, while MarShawn Lloyd’s ankle history (with Green Bay) underscores the risk for Mixon’s timetable. As chatter swirls, draft plans should factor a cautious timeline, possible split work, and a strong fallback in Week 1 projections as the season unfolds.