Miami’s season opener centers on a showdown between the Dolphins’ elite front seven and the Colts’ experienced, well-regarded offensive line. If Miami can clamp down on Jonathan Taylor and force Indianapolis into a one-dimensional attack, its pass rushers can feast and blow up the pocket. The Colts counter with Nelson and Raimann anchoring an O-line that Pro Football Focus labeled top-five in its 2025 preseason rankings, designed to protect Daniel Jones and open lanes for Taylor.

Key to the Dolphins’ plan is Minkah Fitzpatrick’s veteran leadership and the unit’s depth and athleticism at every level. On offense, Tua Tagovailoa will lean on Tyreek Hill and Jaylen Waddle, but the real leverage may come from the defensive line and linebackers creating pressure and forcing mistakes. The matchup will set the tone for each team’s path to victory and has immediate fantasy implications across both sides of the ball.