Week 1’s NFL All-Star offense and defense deliver a blueprint for fantasy success: Josh Allen powers the Bills’ 41-40 comeback with 394 passing yards and dual threat scores, while Derrick Henry and Saquon Barkley anchor the backfield. Puka Nacua, Zay Flowers and Jaxon Smith-Njigba headline the receivers, Brock Bowers shines at TE amid a Week 1 injury, and the O-line trio Alt-Membou-Vorhees-Goncalves with Erik McCoy paves the way. Defenders Myles Garrett, Nnamdi Madubuike, Ed Oliver and Nick Bosa pace the line, with Roquan Smith, Devin White and Harold Landry at LB and a sturdy secondary led by Adebo, Wright, Love and Curl. Special teams shine in Boswell, Cooke and Dike’s performances.

Jonathan Taylor is finally suiting up for Week 1 as Indy leans on a heavy ground game to open the 2025 season against Miami. The backfield features Taylor as the workhorse, with the rookie DJ Giddens waiting for a bigger role and Tyler Goodson providing relief. On the offensive line, Tanor Bortolini and Matt Goncalves step into pivotal roles after moves elsewhere in free agency. Daniel Jones mans the quarterback spot, but Indy’s attack runs through the ground game.

Expect a run-heavy script that aims to soften Miami’s defense and keep Jones efficient in action. Giddens’ sponge-like learning approach and growing chemistry with the line could yield meaningful touches, giving Taylor more rest and creating additional looks for Indy’s offense. The week will test how Indy balances ceiling with floor in a season-opening showdown.

Miami’s defensive front, led by Zach Seiler and Jaelan Phillips with Bradley Chubb chasing pressure, faces a Colts O-line that features Tanor Bortolini and Matt Goncalves entering full-time duty inside. Movement on the back end and Weaver’s scheme complicate decisions for the Colts’ QB, making interior protection and run establishment critical as they navigate a learning curve for two first-time starters.

Two rookie anchors and a stifling edge duo could tilt the balance, pushing the Colts to rely on discipline up front and quick, decisive plays. The matchup hinges on whether Indianapolis can control the line of scrimmage and whether Miami’s interior push and edge pressure disrupts timing in the Colts’ somemissed opportunities, shaping early-season fantasy leverage on both sides.

Indianapolis is counting on a younger, less experienced offensive line this season. Tanor Bortolini and Matt Goncalves step into starting roles at center and right guard, while rookie Jalen Travis serves as the swing tackle. Second-year Dalton Tucker and Luke Tenuta provide interior and edge depth, with Bernhard Raimann, Quenton Nelson, Braden Smith, and Danny Pinter anchoring the group. Ballard lauds Travis’s rapid development and Tenuta’s versatility as the unit forges cohesion to open the run game and buy time for the quarterback.

ESPN’s Solak highlighted Bortolini’s preseason film, and Ballard emphasized that the staff is pleased with Travis and Tucker. The Colts aim to balance youth with veteran steadiness to create sustainable run production and pocket time, accepting some tradeoffs in consistency as they grow together in camp and preseason work.

Riley Leonard led the Colts in a 41-14 preseason win over Cincinnati, completing 15 of 20 for 189 yards and delivering a 59-yard TD to Laquon Treadwell in the first half. Indianapolis leaned on Leonard’s mobility to extend plays, while Shane Steichen designed plays to get him out of the pocket. The defense limited Cincinnati’s passing to under 100 yards, but the Bengals exploited the run game for 132 on 23 carries. Standouts Isaiah Land, Daniel Scott and Treadwell pushed final roster decisions, and the ball on Leonard’s TD pass was saved for him by Anthony Richardson after his first NFL TD. The game offered a clear snapshot of Colts depth and fantasy angles as rosters finalize later this week.