Week 3 NFL Pick'em Pool locks, semi-confident picks and toss-ups guide lineups with a focus on early-season trends. Indianapolis stands out as an under-the-radar heater, while Kansas City faces a road test against a potent Giants defense and Russell Wilson. The piece blends advanced stats, matchup edges, and injury/coaching notes to sharpen DFS and traditional pools for a high-variance Week 3.

Expect Jonathan Taylor’s workload and Daniel Jones’s distributing ability to shape fantasy outcomes, with Green Bay’s improved defense and a few tight-divisional matchups elevating several starts. The guide emphasizes edge plays, risk-reward decisions, and how week-to-week volatility can swing contests in both daily and season-long formats.

Injury news, rest-of-season implications, and coaching decisions are woven in to sour or sweeten upside across multiple games, helping fantasy players calibrate locks, semi-confident picks, and toss-ups for optimal Week 3 strategies.

Buffalo’s high-octane offense (35.5 ppg) hosts a reeling Miami squad that has yielded 33 points in each of its first two games. Buffalo is a 12-point favorite with a 49.5-point total, and simulations peg Buffalo to cover roughly 57% of the time and the Over around 67%. Expect Josh Allen to pace a shootout against Miami’s vulnerable defense, while Miami’s healthy Tua Tagovailoa tries to keep pace for fantasy managers.

Buffalo owns a commanding recent edge, winning 13 of 14 meetings (including playoffs). Kickoff is 8:15 p.m. ET at Highmark Stadium. The game sets up as a strong fantasy play for Bills pass-catchers and a challenging but intriguing option for Dolphins, with the betting line and model leaning toward a high-scoring, Buffalo-led night for Week 3.