Pro Football Focus has ranked six Indianapolis Colts defenders among the top players at their respective positions for the upcoming 2025 NFL season. DeForest Buckner leads the crew at 8th among interior defensive linemen, recognized for his impressive metrics in pass rush win rate, productivity, and run-stop rate. Grover Stewart follows at 24th in the same category, showcasing his strong run defense capability.

Additionally, the Colts have made significant offseason enhancements to their secondary, signing Charvarius Ward and Cam Bynum, as well as drafting Justin Walley in the top 100. New defensive coordinator Lou Anarumo is implementing a more aggressive scheme expected to elevate the entire unit's performance.