Arizona visits Indianapolis in Week 6 as underdogs, with Alec Pierce returning and Kenny Moore out, setting up a potentially sharper Colts aerial attack and a nickel spot to monitor in Chris Lammons. The Colts’ front continues to trend toward consistency, led by Laiatu Latu while Grover Stewart’s health adds interior mass. Jonathan Taylor remains a fantasy staple, and Tyler Warren’s mid-range role tightens Indianapolis’ target tree. Kansas City-style efficiency from Steichen’s scheme is noted as a blueprint even in tough losses, boosting fantasy intrigue around Colts playmakers.

Daniel Jones’ breakout efficiency is cited as a blueprint for steady QB performance in similar schemes, underscoring the Colts’ philosophy on game plan and ball distribution. The Cardinals’ offense will test Indy’s pass rush, aiming to keep pace with a trusted, balanced attack. The preview forecasts a tight battle with a projected Colts edge at 24-20, hinging on the Indianapolis defense’s ability to pressure and finish and on Pierce’s impact returning to the field.