Colts' Week 2 depth chart faces a reshuffle with Charvarius Ward out and Jaylon Jones sidelined, testing the secondary against Denver. Kenny Moore II returns, while Mekhi Blackmon, Jonathan Edwards, and Xavien Howard join the corner rotation; Laiatu Latu may be limited by a hamstring. A Week 1 defensive masterclass by Lou Anarumo looms as Indianapolis aims to repeat, but fantasy managers must gauge CB usage and Broncos passing attack dynamics.