Denver aims to flip a historical rough start by opening 2-0, leaning on a veteran defense and a run-heavy attack as Payton rebuilds the offense around Bo Nix. Indy arrives with a refreshed vibe and Daniel Jones orchestrating seven straight scoring drives in Week 1, setting up a clash of Denver’s defensive prowess against Indy’s high-functioning new-look unit.

For fantasy managers, Nix’s turnover risk vs. Indy’s secondary and Jones’ quick-strike rhythm against Denver’s defense are the key storyline drivers. Monitor how the Broncos protect the ball and control pace, while Indy tests Denver’s back-end and pressure at Lucas Oil. Week 2 fantasy pivots hinge on game-script and run/throw balance.

A Colts roster vacancy opened when Jaylon Jones was placed on injured reserve, leaving Indianapolis at 52 players ahead of Week 2 with Denver on the horizon. The team has not filled the spot yet, but has already bolstered cornerback depth by elevating Chris Lammons and adding Ulysess Bentley for depth and special-teams value.

With Ward sidelined by concussion protocols, cornerback depth is the obvious target, and Lammons—familiar with Lou Anarumo’s system—looks like the most likely fit. A linebacker addition remains a possibility, as the club has brought in bodies for workouts since training camp. The move could come Monday or Tuesday to maximize practice reps before the third game.

Five bold Week 2 predictions for Denver vs. Indianapolis shape a fantasy-friendly path: a 200+-yard rushing onslaught with one back eclipsing 100 yards; Bo Nix climbs to 70% completions with 200 passing yards, a touchdown and no interceptions, while the offense emphasizes the run early. Denver’s defense eyes a six-sack performance from different players, including a secondary contributor, plus three takeaways. Jeremy Crawshaw bumps to a 49.5-yard punt average on a handful of tries, while Payton’s plan leans into ball control and field-position leverage.

The Colts’ run defense is vulnerable, even as their pass defense shines; if Denver can sustain the ground game, the game plan should unlock better efficiency for Nix and keep the chains moving. The piece uses a Giants scenario to illustrate pressure-induced turnovers, underscoring how the Broncos’ defense and special teams could swing outcomes in a close contest. For fantasy bettors, focus on the running back workload, Nix’s efficiency, sack distribution, and Crawshaw’s punting windows.

Miami's right side is in flux as Austin Jackson lands on IR and James Daniels joins him, forcing a reshaped O-line for at least four games. Borom steps in at right tackle with Kion Smith sliding to right guard; Strange, Brunskill or Lamm may inherit later opportunities. Waller remains in the lineup with a two-TE look, and Wilson Jr. plus Patterson get practice-squad elevations to stay ready. Cornell Armstrong moves up to fifth cornerback as Bonner sits, while Wright is doubtful and Waller stays active.

Depth and tempo become the x-factors: the Dolphins will lean on internal depth, situational protection schemes, and occasional run-game adjustments against a brutal early schedule (Patriots, Bills, Jets, Panthers). The earliest Jackson or Daniels could return is Week 6 vs Chargers, giving Miami a light at the end of the tunnel as Eichenberg works off PUP. Fantasy angles hinge on who seizes the opportunistic reps along the line and how the TE and RB options are deployed in the shift.