Week 2 fantasy lineups hinge on clear roles and favorable matchups. Garrett Wilson should soak up targets against Buffalo, while Travis Etienne Jr. benefits from Tank Bigsby’s trade leaving him with extra touches in Jacksonville. Calvin Ridley’s volume remains solid despite a tougher matchup, and D.J. Moore projects steady targets facing Detroit. Marquise Brown could command looks with Kansas City short on WR depth, creating upside as a viable start in many leagues.

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Seattle’s backfield is unsettled after Week 1, with Charbonnet thriving on early downs and Walker III’s snap share slipping. Week 2 against Pittsburgh could tilt toward the rookie, making Walker more of a high-end FLEX than a locked RB2. Conner’s heavy committee in Arizona raises red flags; Week 2 hosts Carolina, a tough matchup that could cap his volume. Indianapolis’ Downs disappointed again Week 1 as Pittman Jr. dominates targets, while Warren’s 9 targets signal a TE/H-back heavy approach that could squeeze Downs. Baltimore’s Andrews was TD-dependent in Week 1 and needs red-zone chances to pay off. QB volatility showed with Burrow and Prescott being outperformed by Spencer Rattler in Week 1, a fluky outlier that should settle, but Week 2 still demands cautious rostering.

Christian Kirk's return date remains uncertain as hamstring issues shadow Week 2. Houston's offense bulks up around Nico Collins, CJ Stroud's quick reads, and the Texans' slot targets if Kirk sits. Week 1 saw limited involvement for Kirk with rookies Higgins and Noel stepping up; Week 2 could test Houston's caution and Collins' bump in the target tree.

Owners should stash Kirk on bench in shallow leagues, while Collins becomes a viable week-to-week WR3/flex if Kirk is out. Stroud's penchant for quick completions could lift Collins' fantasy floor, and Hutchinson's slot role may provide a reliable floor if Kirk remains sidelined. Houston's Week 2 matchup vs Tampa Bay will be telling for how the passing game rebalances without Kirk.