Kenny Moore II’s knee injury during Colts camp is not described as a major setback, ESPN notes, but a firm timeline remains unclear. With Moore out of practice and a string of cornerback injuries (Justin Walley ACL, Jaylon Jones and JuJu Brents hamstrings), Indianapolis faces a reshaped depth chart. Charvarius Ward anchors outside, while Samuel Womack III, Alex Johnson and Johnathan Edwards are in the mix to start opposite Ward. Moore has been a steady presence, logging over 1,000 defensive snaps in four of the last five seasons and posting three interceptions in 2024 while limiting yards per target. In fantasy terms, a Moore absence could push Womack or Edwards into more prominent roles, elevate Ward’s workload if he’s healthy, and test the Colts’ depth with early-season matchups against high-powered passing offenses.

Depth at CB could swing Week 1 projections for Indy, especially given the surrounding injuries. The trio of potential nickel/dime players—Womack, Johnson and Edwards—offer speculative upside in dynasty leagues or as aone-off stream if Moore’s return lags. As the Colts navigate murky timelines, fantasy managers should monitor practice reps and injury reports closely, because even a short spell without Moore could tilt fantasy value toward the next-man-in at nickel and opposite Ward.