Miami’s defensive front, led by Zach Seiler and Jaelan Phillips with Bradley Chubb chasing pressure, faces a Colts O-line that features Tanor Bortolini and Matt Goncalves entering full-time duty inside. Movement on the back end and Weaver’s scheme complicate decisions for the Colts’ QB, making interior protection and run establishment critical as they navigate a learning curve for two first-time starters.

Two rookie anchors and a stifling edge duo could tilt the balance, pushing the Colts to rely on discipline up front and quick, decisive plays. The matchup hinges on whether Indianapolis can control the line of scrimmage and whether Miami’s interior push and edge pressure disrupts timing in the Colts’ somemissed opportunities, shaping early-season fantasy leverage on both sides.