Week 5 injury watch centers on Tyquan Lewis, who is questionable with an oblique after two limited practices. If Lewis sits, JT Tuimoloau steps into a larger edge role behind a rotation anchored by Laiatu Latu, Samson Ebukam, and Kwity Paye, with Latu handling interior pass rush on certain packages. Fantasy angles shift to Latu’s snap counts and the Colts’ pass rush depth against the Raiders, plus the impact of any fallback options on downs 3-4.

Inactive or not, the storm clouds around the Colts’ DE group could tilt the rotation toward Tuimoloau and increased interior pressure on passing downs. Raiders’ line protections will test the group, so fantasy managers should monitor final inactives and practice reports closely before kickoff.