The Indianapolis Colts will enjoy a favorable early season schedule in 2025, featuring four of their first six games at home, including the season opener against the Miami Dolphins. This heavy home stretch positions them well to build momentum before facing tougher matchups. The only playoff contender among their first five home games is the Denver Broncos, with matchups against the Las Vegas Raiders and Arizona Cardinals also on the horizon.

The Colts' win probabilities against their opening opponents indicate a competitive start, with home games against the Dolphins (51% chance), Broncos (45%), Raiders (64%), and Cardinals (53%). Away games against the Tennessee Titans and LA Rams present tougher challenges, but favorable conditions at Lucas Oil Stadium could significantly impact their performance.