Colts face their first road test at Tennessee after a 2-0 start that leaned on early offense and clutch special teams. Indy sits as a -3.5 favorite with a -166 money line and a 42.5 over/under, signaling a tight, grind-it-out divisional affair. The win over Denver featured a bold start and late heroics from Shrader and Lutz, while the Titans’ rookie Cam Ward has shown upside but finishing drives remains a work in progress.

Fantasy angles hinge on Ward’s early impact and the Colts’ improving weaponry. If Ward can sustain drives, Tennessee’s ceiling rises; if not, Indy’s defense and kicking game could tilt the balance. This matchup sets up as a pivotal early-season test that could define who controls the division and which players emerge as weekly fantasy starters or sit-downs.