Brock Purdy’s turf-toe injury sidelines the 49ers QB for up to five weeks, thrusting Mac Jones into Sunday’s matchup with New Orleans. Fantasy managers should scan the QB streamer list, with Daniel Jones, Trevor Lawrence, and even Aaron Rodgers cited as viable options in tougher spots.

Week 1’s injury avalanche continued with Austin Ekeler’s season-ending Achilles and George Kittle’s hamstring. Add in Xavier Worthy’s shoulder and Brock Bowers’s knee, and the waiver wire becomes a chessboard. Watch for sleepers like Harold Fannin Jr. and Emeka Egbuka to emerge for deeper leagues.

Week 2 waiver targets lean toward steady QBs and backs with clear roles. Stafford’s back-health boost gives a safe Week 2 streamer with Nacua and Adams healthy anchors. Jones brings rushing upside as an Indy QB2, and Gainwell could lock a three-down role in Pittsburgh if Week 1 usage sticks.

Ollie Gordon II, Kaleb Johnson, and Kyle Monangai offer deep-league flier potential, while Boutte’s 103-yard debut makes NEP worth watching. JSN flashed in Seattle, backing the rookie path. Week 2 waivers demand matchup awareness and backfield clarity for late-season pushes.