Brock Purdy’s turf-toe injury sidelines the 49ers QB for up to five weeks, thrusting Mac Jones into Sunday’s matchup with New Orleans. Fantasy managers should scan the QB streamer list, with Daniel Jones, Trevor Lawrence, and even Aaron Rodgers cited as viable options in tougher spots.

Week 1’s injury avalanche continued with Austin Ekeler’s season-ending Achilles and George Kittle’s hamstring. Add in Xavier Worthy’s shoulder and Brock Bowers’s knee, and the waiver wire becomes a chessboard. Watch for sleepers like Harold Fannin Jr. and Emeka Egbuka to emerge for deeper leagues.

Calvin Ridley enters Week 2 as Tennessee's clear WR1, but his upside is capped by Cam Ward's rookie transition and a Rams defense that was stingy with WRs last week. After a rough opener against Denver, Ridley's floor remains solid in PPR as a mid-range WR3, with limited big-play upside in standard formats. In shallow leagues or if the Titans lean on Week 2 volume, Ridley remains a viable flex option.

Titans reshuffle ahead of Week 2 versus the Rams: Corey Levin is promoted from the practice squad to the 53-man roster to bolster interior line depth behind Lloyd Cushenberry as he returns from a torn Achilles. Brandon Crenshaw-Dickson is waived, while Jordan Mims and John Ojukwu are elevated from the practice squad to provide additional depth with JC Latham sidelined and Kalel Mullings doubtful. Tennessee aims to lean on protection and run game at Nissan Stadium.

Christian Kirk will miss a second straight Texans game with a hamstring, leaving Nico Collins, Xavier Hutchinson and Justin Watson to pace Monday night’s attack against Tampa Bay. Braxton Berrios is out too, and rookies Jayden Higgins and Jaylin Noel could see extra targets as Tank Dell’s 2025 absence looms large.

Weeks 3 vs Jacksonville could finally bring Kirk back, a reunion with his former team that would reshape Houston’s target share and lift the value of the top three receivers and the rookies stepping in now.