On May 23, 2025, the Seattle Mariners (28-21) face off against the Houston Astros (26-24) at Minute Maid Park. Mariners' Emerson Hancock, with a 1-2 record and a 6.21 ERA, will pitch against the Astros' Ryan Gusto, who has a 3-2 record and a 4.65 ERA. The Astros lost their first game of the series 9-2, with Lance McCullers Jr. securing the win after striking out eight batters.

The odds for this matchup suggest a close game, with the Mariners at +101 on the moneyline and the Astros at -121. Bettors are also intrigued by the spread, where the Astros are favored by 1.5 runs, and the total set at 8.0 runs. The latest trends show the Astros winning 4 of their last 5 home games. Meanwhile, the Mariners have struggled to cover the run line in their past three games. Expert predictions recommend betting on the Astros to win on the moneyline and taking the Mariners at +1.5.