Buffalo loaded up on defense in the 2025 draft, banking on interior disruption from Sanders and Walker. Their strong preseason showing — each at 15.4% pass rush win rate — could unlock more interior pressure for Ed Oliver and push DeWayne Carter toward a smaller role or inactive days, depending on how quickly the rookies lock in. If they deliver, the Bills’ front could be a surprisingly sturdy fantasy asset, with additional upside if the duo earns consistent snaps.

Buffalo s preseason finale highlighted Deone Walker s breakout in 21 snaps, delivering four tackles, half a sack and a tackle for loss, signaling a potential year-one interior disruption for the Bills.

Hairston s injury cloud and Tre Davius White s ankle concern heighten roster volatility, opening doors for late-round rookies and versatile veterans in the defensive front and secondary. Ed Oliver anchors the middle, while DL and OL depth players like Landon Jackson and Chase Lundt flashed, shaping a depth-chart drama that will influence Week 1 fantasy projections.

Buffalo at Chicago in primetime Week 2 of the preseason hinges on depth-chart theater more than box-score glamour. Mitch Trubisky is slated as QB2 with the job to lose, and the night offers a clear chance to prove pocket poise and smart decision-making against his former club. Curtis Samuel and Elijah Moore stand out as potential breakout plays if healthy, with Moore especially positioned to seize a prominent role amid a thinner Bills WR corps. On defense, Buffalo looks to rookies Deone Walker and TJ Sanders to stack meaningful snaps, while Ed Oliver, DaQuan Jones and Larry Ogunjobi push the interior, and Tre’Von Edmunds squanders no opportunity against his old teammates. The safety group—Damar Hamlin, Taylor Rapp, and Cole Bishop—needs reps to validate Babich’s plans, with Samuel’s status adding another layer of intrigue.

Giants and Bills opened Week 1 of the NFL preseason with New York pulling ahead 34-25 behind a lively QB rotation. Jaxson Dart flashed, completing 12 of 19 passes for 154 yards and adding 24 rushing yards, capping a drive with a deep, perfectly placed end-zone shot. He, along with Jameis Winston and Tommy DeVito, gave the Giants a multi-headed approach that kept the offense productive in chunks. Buffalo countered with a surgical pass rush from Deone Walker, who finished with three QB pressures and led the game in pass-rush win rate, while Abdul Carter and Trace Ford also elicited pressure on the edges.

The box score paints a balanced picture: 76 Giants plays to 55 Bills plays, Giants totaling 374 yards to Buffalo’s 404, and both teams finishing red-zone with two TDs. The Giants moved the ball efficiently across multiple quarterbacks, while Buffalo’s defense showed inventiveness up front. PFF graders highlighted Walker’s performance as the standout for the Bills in a game that also featured strong showings from Carter and Ford. Projected fantasy fallout centers on Dart’s ceiling and a possible deeper Giants QB battle, alongside a Bills defense that anchored the effort with interior pressure.

In a broader fantasy context, Week 1 signals that Dart could be a late-season spec for dynasty rosters if his development continues, while Winston and DeVito provide insurance for the Giants’ depth chart. Bills notes are more defensive upside than offensive, but Walker’s disruptive presence invites attention to Buffalo’s run of upcoming preseason snaps. PFF+ promotions aside, this game underscored the value of early career film as teams sort their Week 1 roles.